Toward a model-based patient selection strategy for proton therapy: External validation of photon-derived normal tissue complication probability models in a head and neck proton therapy cohort
نویسندگان
چکیده
منابع مشابه
A new model for Spread Out Bragg Peak in proton therapy of uveal melanoma
In this research, in order to improve our calculations in treatment planning for proton radiotherapy of ocular melanoma, we improved our human eye phantom planning system in GEANT4 toolkit. Different analytical models have investigated the creating of Spread Out Bragg Peak (SOBP) in the tumor area. Bortfeld’s model is one of the most important analytical methods. Using convolution method, a new...
متن کاملIncrease in Tumor Control and Normal Tissue Complication Probabilities in Advanced Head-and-Neck Cancer for Dose-Escalated Intensity-Modulated Photon and Proton Therapy
INTRODUCTION Presently used radiochemotherapy regimens result in moderate local control rates for patients with advanced head-and-neck squamous cell carcinoma (HNSCC). Dose escalation (DE) may be an option to improve patient outcome, but may also increase the risk of toxicities in healthy tissue. The presented treatment planning study evaluated the feasibility of two DE levels for advanced HNSC...
متن کاملEvaluation of Tumor Control and Normal Tissue Complication Probability in Head and Neck Cancers with Different Sources of Radiation: A Comparative Study
Introduction: The ultimate goal of radiation treatment planning is to yield a high tumor control probability (TCP) with a low normal tissue complication probability (NTCP). Historically dose volume histogram (DVH) with only volumetric dose distribution was utilized as a popular tool for plan evaluation hence present study aimed to compare the radiobiological effectiveness of the cobalt-60 (Co...
متن کاملReduced Normal Tissue Toxicity with Proton Therapy
Proton beams offer highly significant advantages over X-rays in the sparing of normal tissues. This is due to the physical characteristics of the proton beam compared to X-rays. X-rays are electromagnetic waves and are highly penetrating, and will deliver dose throughout any volume of tissue irradiated, regardless of thickness. Thus x-rays always deliver substantial doses of irradiation both an...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Radiotherapy and Oncology
سال: 2016
ISSN: 0167-8140
DOI: 10.1016/j.radonc.2016.08.022